Back to first pageBack to first page Centre for Artificial Intelligence of UNL
Browse our site
You are here:

Publication details

Go back
Publication details
Main information
Multiple partners in weak interactions.
September 2007
ludi07a
It is difficult to model weak protein-protein interactions because, for transient complexes, the difference between correct and incorrect models may be smaller than the error of the scoring functions and filtering algorithms used to generate those models. One obvious solution is to improve these scoring and filtering methods, and the research community has made significant progress towards that end. But here we will focus on some promising complementary approaches: to use experimental data to narrow the search for correct configurations, to analyse the spatial distribution of large number of configurations generated, and to compare such patterns for dockings with different partners. The goal is to use large numbers of models to be able to discriminate based on more precise statistical information, and to compare different partners to generate baselines and estimate the most appropriate scoring methods for each case.
In proceedings
Ludwig Krippahl
2nd European Conference on Chemistry for Life Sciences
-
Medimond
-
-
-
-
-
-
-
Export formats
Ludwig Krippahl, Multiple partners in weak interactions., , 2nd European Conference on Chemistry for Life Sciences, Medimond, September 2007.
<a href="/people/members/view.php?code=195d68ea5904b58472fd8c8aedcae233" class="author">Ludwig Krippahl</a>, <b>Multiple partners in weak interactions.</b>, <u>2nd European Conference on Chemistry for Life Sciences</u>, <a href="http://www.medimond.com/" title="Link to external entity..." target="_blank" class="publisher">Medimond</a>, September 2007.
@inproceedings {ludi07a, author = {Ludwig Krippahl}, title = {Multiple partners in weak interactions.}, booktitle = {2nd European Conference on Chemistry for Life Sciences}, publisher = {Medimond}, abstract = {It is difficult to model weak protein-protein interactions because, for transient complexes, the difference between correct and incorrect models may be smaller than the error of the scoring functions and filtering algorithms used to generate those models. One obvious solution is to improve these scoring and filtering methods, and the research community has made significant progress towards that end. But here we will focus on some promising complementary approaches: to use experimental data to narrow the search for correct configurations, to analyse the spatial distribution of large number of configurations generated, and to compare such patterns for dockings with different partners. The goal is to use large numbers of models to be able to discriminate based on more precise statistical information, and to compare different partners to generate baselines and estimate the most appropriate scoring methods for each case.}, month = {September}, year = {2007}, }
Publication's urls
/publications/view.php?code=f9e7a51329363b08f6bdb7e334220402
/publications/view.php?code=ludi07a
Go back
Centre for Artificial Intelligence of UNL
Departamento de Informática, FCT/UNL
Quinta da Torre 2829-516 CAPARICA - Portugal
Tel. (+351) 21 294 8536 FAX (+351) 21 294 8541

Fundacao_FCT